Lipoteichoic Acid Is Involved in the Ability of the Immunobiotic Strain Lactobacillus plantarum CRL1506 to Modulate the Intestinal Antiviral Innate Immunity Triggered by TLR3 Activation.
Identifieur interne : 000121 ( Main/Exploration ); précédent : 000120; suivant : 000122Lipoteichoic Acid Is Involved in the Ability of the Immunobiotic Strain Lactobacillus plantarum CRL1506 to Modulate the Intestinal Antiviral Innate Immunity Triggered by TLR3 Activation.
Auteurs : Hiroya Mizuno [Japon] ; Lorena Arce [Argentine] ; Kae Tomotsune [Japon] ; Leonardo Albarracin [Japon, Argentine] ; Ryutaro Funabashi [Japon] ; Daniela Vera [Argentine] ; Md Aminul Islam [Japon, Bangladesh] ; Maria Guadalupe Vizoso-Pinto [Argentine] ; Hideki Takahashi [Japon] ; Yasuko Sasaki [Japon] ; Haruki Kitazawa [Japon] ; Julio Villena [Japon, Argentine]Source :
- Frontiers in immunology [ 1664-3224 ] ; 2020.
Abstract
Studies have demonstrated that lipoteichoic acid (LTA) is involved in the immunomodulatory properties of some immunobiotic lactobacilli. The aim of this work was to evaluate whether LTA contributes to the capacity of Lactobacillus plantarum CRL1506 in modulating the intestinal innate antiviral immune response. A D-alanyl-lipoteichoic acid biosynthesis protein (dltD) knockout CRL1506 strain (L. plantarumΔdltD) was obtained, and its ability to modulate Toll-like receptor (TLR)-3-mediated immune response was evaluated in vitro in porcine intestinal epithelial (PIE) cells and in vivo in Balb/c mice. Wild-type (WT) CRL1506 (L. plantarum WT) was used as positive control. The challenge of PIE cells with the TLR3 agonist poly(I:C) significantly increased interferon (IFN)-β, interleukin (IL)-6, and monocyte chemoattractant protein (MCP)-1 expressions. PIE cells pretreated with L. plantarumΔdltD or L. plantarum WT showed higher levels of IFN-β while only L. plantarum WT significantly reduced the expression of IL-6 and MCP-1 when compared with poly(I:C)-treated control cells. The oral administration of L. plantarum WT to mice prior the intraperitoneal injection of poly(I:C) significantly increased IFN-β and IL-10 and reduced intraepithelial lymphocytes (CD3+NK1.1+CD8αα+) and pro-inflammatory mediators (TNF-α, IL-6, and IL-15) in the intestinal mucosa. Similar to the WT strain, L. plantarumΔdltD-treated mice showed enhanced levels of IFN-β after poly(I:C) challenge. However, treatment of mice with L. plantarumΔdltD was not able to increase IL-10 or reduce CD3+NK1.1+CD8αα+ cells, TNF-α, IL-6, or IL-15 in the intestine. These results indicate that LTA would be a key molecule in the anti-inflammatory effect induced by the CRL1506 strain in the context of TLR3-mediated inflammation.
DOI: 10.3389/fimmu.2020.00571
PubMed: 32328062
PubMed Central: PMC7161159
Affiliations:
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Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Laboratory of Immunobiotechnology, Reference Centre for Lactobacilli (CERELA-CONICET), Tucuman</wicri:regionArea><wicri:noRegion>Tucuman</wicri:noRegion></affiliation></author><author><name sortKey="Funabashi, Ryutaro" sort="Funabashi, Ryutaro" uniqKey="Funabashi R" first="Ryutaro" last="Funabashi">Ryutaro Funabashi</name><affiliation wicri:level="4"><nlm:affiliation>Food and Feed Immunology Group, Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Food and Feed Immunology Group, Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Sendai</wicri:regionArea><orgName type="university">Université du Tōhoku</orgName><placeName><settlement type="city">Sendai</settlement><region type="province">Région de Tōhoku</region></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Livestock Immunology Unit, International Education and Research Center for Food Agricultural Immunology, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Livestock Immunology Unit, International Education and Research Center for Food Agricultural Immunology, Graduate School of Agricultural Science, Tohoku University, Sendai</wicri:regionArea><orgName type="university">Université du Tōhoku</orgName><placeName><settlement type="city">Sendai</settlement><region type="province">Région de Tōhoku</region></placeName></affiliation></author><author><name sortKey="Vera, Daniela" sort="Vera, Daniela" uniqKey="Vera D" first="Daniela" last="Vera">Daniela Vera</name><affiliation wicri:level="1"><nlm:affiliation>Infection Biology Laboratory, Instituto Superior de Investigaciones Biológicas (INSIBIO), CONICET-UNT, Tucumán, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Infection Biology Laboratory, Instituto Superior de Investigaciones Biológicas (INSIBIO), CONICET-UNT, Tucumán</wicri:regionArea><wicri:noRegion>Tucumán</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Laboratorio de Ciencias Básicas Or. Genética, Facultad de Medicina de la Universidad Nacional de Tucuman, Tucumán, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Laboratorio de Ciencias Básicas Or. Genética, Facultad de Medicina de la Universidad Nacional de Tucuman, Tucumán</wicri:regionArea><wicri:noRegion>Tucumán</wicri:noRegion></affiliation></author><author><name sortKey="Islam, Md Aminul" sort="Islam, Md Aminul" uniqKey="Islam M" first="Md Aminul" last="Islam">Md Aminul Islam</name><affiliation wicri:level="4"><nlm:affiliation>Food and Feed Immunology Group, Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Food and Feed Immunology Group, Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Sendai</wicri:regionArea><orgName type="university">Université du Tōhoku</orgName><placeName><settlement type="city">Sendai</settlement><region type="province">Région de Tōhoku</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh, Bangladesh.</nlm:affiliation><country xml:lang="fr">Bangladesh</country><wicri:regionArea>Department of Medicine, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh</wicri:regionArea><wicri:noRegion>Mymensingh</wicri:noRegion></affiliation></author><author><name sortKey="Vizoso Pinto, Maria Guadalupe" sort="Vizoso Pinto, Maria Guadalupe" uniqKey="Vizoso Pinto M" first="Maria Guadalupe" last="Vizoso-Pinto">Maria Guadalupe Vizoso-Pinto</name><affiliation wicri:level="1"><nlm:affiliation>Infection Biology Laboratory, Instituto Superior de Investigaciones Biológicas (INSIBIO), CONICET-UNT, Tucumán, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Infection Biology Laboratory, Instituto Superior de Investigaciones Biológicas (INSIBIO), CONICET-UNT, Tucumán</wicri:regionArea><wicri:noRegion>Tucumán</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Laboratorio de Ciencias Básicas Or. Genética, Facultad de Medicina de la Universidad Nacional de Tucuman, Tucumán, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Laboratorio de Ciencias Básicas Or. Genética, Facultad de Medicina de la Universidad Nacional de Tucuman, Tucumán</wicri:regionArea><wicri:noRegion>Tucumán</wicri:noRegion></affiliation></author><author><name sortKey="Takahashi, Hideki" sort="Takahashi, Hideki" uniqKey="Takahashi H" first="Hideki" last="Takahashi">Hideki Takahashi</name><affiliation wicri:level="4"><nlm:affiliation>Plant Immunology Unit, International Education and Research Center for Food Agricultural Immunology, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Plant Immunology Unit, International Education and Research Center for Food Agricultural Immunology, Graduate School of Agricultural Science, Tohoku University, Sendai</wicri:regionArea><orgName type="university">Université du Tōhoku</orgName><placeName><settlement type="city">Sendai</settlement><region type="province">Région de Tōhoku</region></placeName></affiliation></author><author><name sortKey="Sasaki, Yasuko" sort="Sasaki, Yasuko" uniqKey="Sasaki Y" first="Yasuko" last="Sasaki">Yasuko Sasaki</name><affiliation wicri:level="1"><nlm:affiliation>Graduate School of Agriculture, Meiji University, Kawasaki, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Graduate School of Agriculture, Meiji University, Kawasaki</wicri:regionArea><wicri:noRegion>Kawasaki</wicri:noRegion></affiliation></author><author><name sortKey="Kitazawa, Haruki" sort="Kitazawa, Haruki" uniqKey="Kitazawa H" first="Haruki" last="Kitazawa">Haruki Kitazawa</name><affiliation wicri:level="4"><nlm:affiliation>Food and Feed Immunology Group, Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Food and Feed Immunology Group, Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Sendai</wicri:regionArea><orgName type="university">Université du Tōhoku</orgName><placeName><settlement type="city">Sendai</settlement><region type="province">Région de Tōhoku</region></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Livestock Immunology Unit, International Education and Research Center for Food Agricultural Immunology, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Livestock Immunology Unit, International Education and Research Center for Food Agricultural Immunology, Graduate School of Agricultural Science, Tohoku University, Sendai</wicri:regionArea><orgName type="university">Université du Tōhoku</orgName><placeName><settlement type="city">Sendai</settlement><region type="province">Région de Tōhoku</region></placeName></affiliation></author><author><name sortKey="Villena, Julio" sort="Villena, Julio" uniqKey="Villena J" first="Julio" last="Villena">Julio Villena</name><affiliation wicri:level="4"><nlm:affiliation>Food and Feed Immunology Group, Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Food and Feed Immunology Group, Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Sendai</wicri:regionArea><orgName type="university">Université du Tōhoku</orgName><placeName><settlement type="city">Sendai</settlement><region type="province">Région de Tōhoku</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Immunobiotechnology, Reference Centre for Lactobacilli (CERELA-CONICET), Tucuman, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Laboratory of Immunobiotechnology, Reference Centre for Lactobacilli (CERELA-CONICET), 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sort="Mizuno, Hiroya" uniqKey="Mizuno H" first="Hiroya" last="Mizuno">Hiroya Mizuno</name><affiliation wicri:level="4"><nlm:affiliation>Food and Feed Immunology Group, Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Food and Feed Immunology Group, Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Sendai</wicri:regionArea><orgName type="university">Université du Tōhoku</orgName><placeName><settlement type="city">Sendai</settlement><region type="province">Région de Tōhoku</region></placeName></affiliation></author><author><name sortKey="Arce, Lorena" sort="Arce, Lorena" uniqKey="Arce L" first="Lorena" last="Arce">Lorena Arce</name><affiliation wicri:level="1"><nlm:affiliation>Infection Biology Laboratory, Instituto Superior de Investigaciones Biológicas (INSIBIO), CONICET-UNT, Tucumán, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Infection Biology Laboratory, Instituto Superior de Investigaciones Biológicas (INSIBIO), CONICET-UNT, Tucumán</wicri:regionArea><wicri:noRegion>Tucumán</wicri:noRegion></affiliation></author><author><name sortKey="Tomotsune, Kae" sort="Tomotsune, Kae" uniqKey="Tomotsune K" first="Kae" last="Tomotsune">Kae Tomotsune</name><affiliation wicri:level="4"><nlm:affiliation>Food and Feed Immunology Group, Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Food and Feed Immunology Group, Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Sendai</wicri:regionArea><orgName type="university">Université du Tōhoku</orgName><placeName><settlement type="city">Sendai</settlement><region type="province">Région de Tōhoku</region></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Livestock Immunology Unit, International Education and Research Center for Food Agricultural Immunology, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Livestock Immunology Unit, International Education and Research Center for Food Agricultural Immunology, Graduate School of Agricultural Science, Tohoku University, Sendai</wicri:regionArea><orgName type="university">Université du Tōhoku</orgName><placeName><settlement type="city">Sendai</settlement><region type="province">Région de Tōhoku</region></placeName></affiliation></author><author><name sortKey="Albarracin, Leonardo" sort="Albarracin, Leonardo" uniqKey="Albarracin L" first="Leonardo" last="Albarracin">Leonardo Albarracin</name><affiliation wicri:level="4"><nlm:affiliation>Food and Feed Immunology Group, Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Food and Feed Immunology Group, Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Sendai</wicri:regionArea><orgName type="university">Université du Tōhoku</orgName><placeName><settlement type="city">Sendai</settlement><region type="province">Région de Tōhoku</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Immunobiotechnology, Reference Centre for Lactobacilli (CERELA-CONICET), Tucuman, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Laboratory of Immunobiotechnology, Reference Centre for Lactobacilli (CERELA-CONICET), Tucuman</wicri:regionArea><wicri:noRegion>Tucuman</wicri:noRegion></affiliation></author><author><name sortKey="Funabashi, Ryutaro" sort="Funabashi, Ryutaro" uniqKey="Funabashi R" first="Ryutaro" last="Funabashi">Ryutaro Funabashi</name><affiliation wicri:level="4"><nlm:affiliation>Food and Feed Immunology Group, Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Food and Feed Immunology Group, Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Sendai</wicri:regionArea><orgName type="university">Université du Tōhoku</orgName><placeName><settlement type="city">Sendai</settlement><region type="province">Région de Tōhoku</region></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Livestock Immunology Unit, International Education and Research Center for Food Agricultural Immunology, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Livestock Immunology Unit, International Education and Research Center for Food Agricultural Immunology, Graduate School of Agricultural Science, Tohoku University, Sendai</wicri:regionArea><orgName type="university">Université du Tōhoku</orgName><placeName><settlement type="city">Sendai</settlement><region type="province">Région de Tōhoku</region></placeName></affiliation></author><author><name sortKey="Vera, Daniela" sort="Vera, Daniela" uniqKey="Vera D" first="Daniela" last="Vera">Daniela Vera</name><affiliation wicri:level="1"><nlm:affiliation>Infection Biology Laboratory, Instituto Superior de Investigaciones Biológicas (INSIBIO), CONICET-UNT, Tucumán, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Infection Biology Laboratory, Instituto Superior de Investigaciones Biológicas (INSIBIO), CONICET-UNT, Tucumán</wicri:regionArea><wicri:noRegion>Tucumán</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Laboratorio de Ciencias Básicas Or. Genética, Facultad de Medicina de la Universidad Nacional de Tucuman, Tucumán, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Laboratorio de Ciencias Básicas Or. Genética, Facultad de Medicina de la Universidad Nacional de Tucuman, Tucumán</wicri:regionArea><wicri:noRegion>Tucumán</wicri:noRegion></affiliation></author><author><name sortKey="Islam, Md Aminul" sort="Islam, Md Aminul" uniqKey="Islam M" first="Md Aminul" last="Islam">Md Aminul Islam</name><affiliation wicri:level="4"><nlm:affiliation>Food and Feed Immunology Group, Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Food and Feed Immunology Group, Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Sendai</wicri:regionArea><orgName type="university">Université du Tōhoku</orgName><placeName><settlement type="city">Sendai</settlement><region type="province">Région de Tōhoku</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh, Bangladesh.</nlm:affiliation><country xml:lang="fr">Bangladesh</country><wicri:regionArea>Department of Medicine, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh</wicri:regionArea><wicri:noRegion>Mymensingh</wicri:noRegion></affiliation></author><author><name sortKey="Vizoso Pinto, Maria Guadalupe" sort="Vizoso Pinto, Maria Guadalupe" uniqKey="Vizoso Pinto M" first="Maria Guadalupe" last="Vizoso-Pinto">Maria Guadalupe Vizoso-Pinto</name><affiliation wicri:level="1"><nlm:affiliation>Infection Biology Laboratory, Instituto Superior de Investigaciones Biológicas (INSIBIO), CONICET-UNT, Tucumán, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Infection Biology Laboratory, Instituto Superior de Investigaciones Biológicas (INSIBIO), CONICET-UNT, Tucumán</wicri:regionArea><wicri:noRegion>Tucumán</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Laboratorio de Ciencias Básicas Or. Genética, Facultad de Medicina de la Universidad Nacional de Tucuman, Tucumán, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Laboratorio de Ciencias Básicas Or. Genética, Facultad de Medicina de la Universidad Nacional de Tucuman, Tucumán</wicri:regionArea><wicri:noRegion>Tucumán</wicri:noRegion></affiliation></author><author><name sortKey="Takahashi, Hideki" sort="Takahashi, Hideki" uniqKey="Takahashi H" first="Hideki" last="Takahashi">Hideki Takahashi</name><affiliation wicri:level="4"><nlm:affiliation>Plant Immunology Unit, International Education and Research Center for Food Agricultural Immunology, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Plant Immunology Unit, International Education and Research Center for Food Agricultural Immunology, Graduate School of Agricultural Science, Tohoku University, Sendai</wicri:regionArea><orgName type="university">Université du Tōhoku</orgName><placeName><settlement type="city">Sendai</settlement><region type="province">Région de Tōhoku</region></placeName></affiliation></author><author><name sortKey="Sasaki, Yasuko" sort="Sasaki, Yasuko" uniqKey="Sasaki Y" first="Yasuko" last="Sasaki">Yasuko Sasaki</name><affiliation wicri:level="1"><nlm:affiliation>Graduate School of Agriculture, Meiji University, Kawasaki, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Graduate School of Agriculture, Meiji University, Kawasaki</wicri:regionArea><wicri:noRegion>Kawasaki</wicri:noRegion></affiliation></author><author><name sortKey="Kitazawa, Haruki" sort="Kitazawa, Haruki" uniqKey="Kitazawa H" first="Haruki" last="Kitazawa">Haruki Kitazawa</name><affiliation wicri:level="4"><nlm:affiliation>Food and Feed Immunology Group, Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Food and Feed Immunology Group, Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Sendai</wicri:regionArea><orgName type="university">Université du Tōhoku</orgName><placeName><settlement type="city">Sendai</settlement><region type="province">Région de Tōhoku</region></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Livestock Immunology Unit, International Education and Research Center for Food Agricultural Immunology, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Livestock Immunology Unit, International Education and Research Center for Food Agricultural Immunology, Graduate School of Agricultural Science, Tohoku University, Sendai</wicri:regionArea><orgName type="university">Université du Tōhoku</orgName><placeName><settlement type="city">Sendai</settlement><region type="province">Région de Tōhoku</region></placeName></affiliation></author><author><name sortKey="Villena, Julio" sort="Villena, Julio" uniqKey="Villena J" first="Julio" last="Villena">Julio Villena</name><affiliation wicri:level="4"><nlm:affiliation>Food and Feed Immunology Group, Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Food and Feed Immunology Group, Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Sendai</wicri:regionArea><orgName type="university">Université du Tōhoku</orgName><placeName><settlement type="city">Sendai</settlement><region type="province">Région de Tōhoku</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Immunobiotechnology, Reference Centre for Lactobacilli (CERELA-CONICET), Tucuman, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Laboratory of Immunobiotechnology, Reference Centre for Lactobacilli (CERELA-CONICET), Tucuman</wicri:regionArea><wicri:noRegion>Tucuman</wicri:noRegion></affiliation></author></analytic><series><title level="j">Frontiers in immunology</title><idno type="eISSN">1664-3224</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Studies have demonstrated that lipoteichoic acid (LTA) is involved in the immunomodulatory properties of some immunobiotic lactobacilli. The aim of this work was to evaluate whether LTA contributes to the capacity of <i>Lactobacillus plantarum</i> CRL1506 in modulating the intestinal innate antiviral immune response. A D-alanyl-lipoteichoic acid biosynthesis protein (<i>dltD</i>) knockout CRL1506 strain (<i>L. plantarum</i>Δ<i>dltD</i>) was obtained, and its ability to modulate Toll-like receptor (TLR)-3-mediated immune response was evaluated <i>in vitro</i> in porcine intestinal epithelial (PIE) cells and <i>in vivo</i> in Balb/c mice. Wild-type (WT) CRL1506 (<i>L. plantarum</i> WT) was used as positive control. The challenge of PIE cells with the TLR3 agonist poly(I:C) significantly increased interferon (IFN)-β, interleukin (IL)-6, and monocyte chemoattractant protein (MCP)-1 expressions. PIE cells pretreated with <i>L. plantarum</i>Δ<i>dltD</i> or <i>L. plantarum</i> WT showed higher levels of IFN-β while only <i>L. plantarum</i> WT significantly reduced the expression of IL-6 and MCP-1 when compared with poly(I:C)-treated control cells. The oral administration of <i>L. plantarum</i> WT to mice prior the intraperitoneal injection of poly(I:C) significantly increased IFN-β and IL-10 and reduced intraepithelial lymphocytes (CD3<sup>+</sup>NK1.1<sup>+</sup>CD8αα<sup>+</sup>) and pro-inflammatory mediators (TNF-α, IL-6, and IL-15) in the intestinal mucosa. Similar to the WT strain, <i>L. plantarum</i>Δ<i>dltD</i>-treated mice showed enhanced levels of IFN-β after poly(I:C) challenge. However, treatment of mice with <i>L. plantarum</i>Δ<i>dltD</i> was not able to increase IL-10 or reduce CD3<sup>+</sup>NK1.1<sup>+</sup>CD8αα<sup>+</sup> cells, TNF-α, IL-6, or IL-15 in the intestine. These results indicate that LTA would be a key molecule in the anti-inflammatory effect induced by the CRL1506 strain in the context of TLR3-mediated inflammation.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">32328062</PMID><DateRevised><Year>2020</Year><Month>09</Month><Day>01</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1664-3224</ISSN><JournalIssue CitedMedium="Internet"><Volume>11</Volume><PubDate><Year>2020</Year></PubDate></JournalIssue><Title>Frontiers in immunology</Title><ISOAbbreviation>Front Immunol</ISOAbbreviation></Journal><ArticleTitle>Lipoteichoic Acid Is Involved in the Ability of the Immunobiotic Strain <i>Lactobacillus plantarum</i> CRL1506 to Modulate the Intestinal Antiviral Innate Immunity Triggered by TLR3 Activation.</ArticleTitle><Pagination><MedlinePgn>571</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3389/fimmu.2020.00571</ELocationID><Abstract><AbstractText>Studies have demonstrated that lipoteichoic acid (LTA) is involved in the immunomodulatory properties of some immunobiotic lactobacilli. The aim of this work was to evaluate whether LTA contributes to the capacity of <i>Lactobacillus plantarum</i> CRL1506 in modulating the intestinal innate antiviral immune response. A D-alanyl-lipoteichoic acid biosynthesis protein (<i>dltD</i>) knockout CRL1506 strain (<i>L. plantarum</i>Δ<i>dltD</i>) was obtained, and its ability to modulate Toll-like receptor (TLR)-3-mediated immune response was evaluated <i>in vitro</i> in porcine intestinal epithelial (PIE) cells and <i>in vivo</i> in Balb/c mice. Wild-type (WT) CRL1506 (<i>L. plantarum</i> WT) was used as positive control. The challenge of PIE cells with the TLR3 agonist poly(I:C) significantly increased interferon (IFN)-β, interleukin (IL)-6, and monocyte chemoattractant protein (MCP)-1 expressions. PIE cells pretreated with <i>L. plantarum</i>Δ<i>dltD</i> or <i>L. plantarum</i> WT showed higher levels of IFN-β while only <i>L. plantarum</i> WT significantly reduced the expression of IL-6 and MCP-1 when compared with poly(I:C)-treated control cells. The oral administration of <i>L. plantarum</i> WT to mice prior the intraperitoneal injection of poly(I:C) significantly increased IFN-β and IL-10 and reduced intraepithelial lymphocytes (CD3<sup>+</sup>NK1.1<sup>+</sup>CD8αα<sup>+</sup>) and pro-inflammatory mediators (TNF-α, IL-6, and IL-15) in the intestinal mucosa. Similar to the WT strain, <i>L. plantarum</i>Δ<i>dltD</i>-treated mice showed enhanced levels of IFN-β after poly(I:C) challenge. However, treatment of mice with <i>L. plantarum</i>Δ<i>dltD</i> was not able to increase IL-10 or reduce CD3<sup>+</sup>NK1.1<sup>+</sup>CD8αα<sup>+</sup> cells, TNF-α, IL-6, or IL-15 in the intestine. These results indicate that LTA would be a key molecule in the anti-inflammatory effect induced by the CRL1506 strain in the context of TLR3-mediated inflammation.</AbstractText><CopyrightInformation>Copyright © 2020 Mizuno, Arce, Tomotsune, Albarracin, Funabashi, Vera, Islam, Vizoso-Pinto, Takahashi, Sasaki, Kitazawa and Villena.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Mizuno</LastName><ForeName>Hiroya</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Food and Feed Immunology Group, Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Arce</LastName><ForeName>Lorena</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Infection Biology Laboratory, Instituto Superior de Investigaciones Biológicas (INSIBIO), CONICET-UNT, Tucumán, Argentina.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tomotsune</LastName><ForeName>Kae</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Food and Feed Immunology Group, Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Livestock Immunology Unit, International Education and Research Center for Food Agricultural Immunology, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Albarracin</LastName><ForeName>Leonardo</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Food and Feed Immunology Group, Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Laboratory of Immunobiotechnology, Reference Centre for Lactobacilli (CERELA-CONICET), Tucuman, Argentina.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Funabashi</LastName><ForeName>Ryutaro</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Food and Feed Immunology Group, Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Livestock Immunology Unit, International Education and Research Center for Food Agricultural Immunology, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vera</LastName><ForeName>Daniela</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Infection Biology Laboratory, Instituto Superior de Investigaciones Biológicas (INSIBIO), CONICET-UNT, Tucumán, Argentina.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Laboratorio de Ciencias Básicas Or. Genética, Facultad de Medicina de la Universidad Nacional de Tucuman, Tucumán, Argentina.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Islam</LastName><ForeName>Md Aminul</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>Food and Feed Immunology Group, Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medicine, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh, Bangladesh.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vizoso-Pinto</LastName><ForeName>Maria Guadalupe</ForeName><Initials>MG</Initials><AffiliationInfo><Affiliation>Infection Biology Laboratory, Instituto Superior de Investigaciones Biológicas (INSIBIO), CONICET-UNT, Tucumán, Argentina.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Laboratorio de Ciencias Básicas Or. Genética, Facultad de Medicina de la Universidad Nacional de Tucuman, Tucumán, Argentina.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Takahashi</LastName><ForeName>Hideki</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Plant Immunology Unit, International Education and Research Center for Food Agricultural Immunology, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sasaki</LastName><ForeName>Yasuko</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Graduate School of Agriculture, Meiji University, Kawasaki, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kitazawa</LastName><ForeName>Haruki</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Food and Feed Immunology Group, Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Livestock Immunology Unit, International Education and Research Center for Food Agricultural Immunology, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Villena</LastName><ForeName>Julio</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Food and Feed Immunology Group, Laboratory of Animal Products Chemistry, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Laboratory of Immunobiotechnology, Reference Centre for Lactobacilli (CERELA-CONICET), Tucuman, Argentina.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>04</Month><Day>09</Day></ArticleDate></Article><MedlineJournalInfo><Country>Switzerland</Country><MedlineTA>Front Immunol</MedlineTA><NlmUniqueID>101560960</NlmUniqueID><ISSNLinking>1664-3224</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">D-alanyl-lipoteichoic acid biosynthesis protein mutant</Keyword><Keyword MajorTopicYN="Y">Lactobacillus plantarum CRL1506</Keyword><Keyword MajorTopicYN="Y">immunobiotic</Keyword><Keyword MajorTopicYN="Y">intestinal immunity</Keyword><Keyword MajorTopicYN="Y">lipoteichoic acid</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2019</Year><Month>12</Month><Day>08</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>03</Month><Day>12</Day></PubMedPubDate><PubMedPubDate 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Albarracin</name><name sortKey="Funabashi, Ryutaro" sort="Funabashi, Ryutaro" uniqKey="Funabashi R" first="Ryutaro" last="Funabashi">Ryutaro Funabashi</name><name sortKey="Funabashi, Ryutaro" sort="Funabashi, Ryutaro" uniqKey="Funabashi R" first="Ryutaro" last="Funabashi">Ryutaro Funabashi</name><name sortKey="Islam, Md Aminul" sort="Islam, Md Aminul" uniqKey="Islam M" first="Md Aminul" last="Islam">Md Aminul Islam</name><name sortKey="Kitazawa, Haruki" sort="Kitazawa, Haruki" uniqKey="Kitazawa H" first="Haruki" last="Kitazawa">Haruki Kitazawa</name><name sortKey="Kitazawa, Haruki" sort="Kitazawa, Haruki" uniqKey="Kitazawa H" first="Haruki" last="Kitazawa">Haruki Kitazawa</name><name sortKey="Sasaki, Yasuko" sort="Sasaki, Yasuko" uniqKey="Sasaki Y" first="Yasuko" last="Sasaki">Yasuko Sasaki</name><name sortKey="Takahashi, Hideki" sort="Takahashi, Hideki" uniqKey="Takahashi H" first="Hideki" last="Takahashi">Hideki Takahashi</name><name sortKey="Tomotsune, Kae" sort="Tomotsune, Kae" uniqKey="Tomotsune K" first="Kae" last="Tomotsune">Kae Tomotsune</name><name sortKey="Tomotsune, Kae" sort="Tomotsune, Kae" uniqKey="Tomotsune K" first="Kae" last="Tomotsune">Kae Tomotsune</name><name sortKey="Villena, Julio" sort="Villena, Julio" uniqKey="Villena J" first="Julio" last="Villena">Julio Villena</name></country><country name="Argentine"><noRegion><name sortKey="Arce, Lorena" sort="Arce, Lorena" uniqKey="Arce L" first="Lorena" last="Arce">Lorena Arce</name></noRegion><name sortKey="Albarracin, Leonardo" sort="Albarracin, Leonardo" uniqKey="Albarracin L" first="Leonardo" last="Albarracin">Leonardo Albarracin</name><name sortKey="Vera, Daniela" sort="Vera, Daniela" uniqKey="Vera D" first="Daniela" last="Vera">Daniela Vera</name><name sortKey="Vera, Daniela" sort="Vera, Daniela" uniqKey="Vera D" first="Daniela" last="Vera">Daniela Vera</name><name sortKey="Villena, Julio" sort="Villena, Julio" uniqKey="Villena J" first="Julio" last="Villena">Julio Villena</name><name sortKey="Vizoso Pinto, Maria Guadalupe" sort="Vizoso Pinto, Maria Guadalupe" uniqKey="Vizoso Pinto M" first="Maria Guadalupe" last="Vizoso-Pinto">Maria Guadalupe Vizoso-Pinto</name><name sortKey="Vizoso Pinto, Maria Guadalupe" sort="Vizoso Pinto, Maria Guadalupe" uniqKey="Vizoso Pinto M" first="Maria Guadalupe" last="Vizoso-Pinto">Maria Guadalupe Vizoso-Pinto</name></country><country name="Bangladesh"><noRegion><name sortKey="Islam, Md Aminul" sort="Islam, Md Aminul" uniqKey="Islam M" first="Md Aminul" last="Islam">Md Aminul Islam</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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